![]() ![]() Manual searches, including in bioRxiv and medRxiv, and a bibliographical search were also conducted to obtain additional evidence. Our research is limited to studies involving humans reported in english. We added one eligible study on July 13, 2021. We conducted comprehensive keyword searches, on June 20–22, 2021, to find articles published in trial registries (, the WHO Clinical Trial Registry, and the EU Clinical Trial Registry) and databases (MEDLINE, ScienceDirect, Cochrane Library, Proquest, and Springer). For this reason, we systematically review the latest evidence on Covid-19 vaccination to summarize its efficacy, immunogenicity, and safety profile in pregnant women. ![]() This shows that efforts to prevent SARS-CoV-2 infection, such as by vaccination, are critical for investigations on this population. A previous study revealed that most pregnant women with Covid-19 admitted to hospital were asymptomatic, which allows these undetected patients to transmit the virus to others. ĭespite their higher risk of SARS-CoV-2 infection, pregnant and lactating women were not included in any initial Covid-19 vaccine trials, resulting in a lack of data to guide vaccine decision-making in these populations. Although most pregnant women suffer only mild to moderate symptoms, SARS-CoV-2 infection is more severe in pregnant women than in others, with increased risks of hospital admission, intensive care unit stay, and death. In fact, pregnant women are still at a higher risk of acquiring viral respiratory infections and severe pneumonia due to the unique physiological changes in their immune and cardiopulmonary systems. ![]() The efficacy and safety of Coronavirus disease 2019 (Covid-19) vaccines have been demonstrated in adults across a range of demographics, but their impact on pregnant women remain unclear due to insufficient information being available. One of the most effective approaches is vaccination against severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2). Since the beginning of the Covid-19 pandemic, extensive efforts have been made to end this global disaster. ![]()
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